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Avandia (ROSIGLITAZONE) is an anti-diabetic drug (thiazolidinedione-type, also called "glitazones") used with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes (non-insulin-dependent diabetes). Rosiglitazone works by helping to restore your body's proper response to insulin, thereby lowering your blood sugar. Effectively controlling high blood sugar helps prevent heart disease, strokes, kidney disease, blindness, and circulation problems, as well as sexual function problems (impotence).
Rosiglitazone is best used only when other medications (metformin) cannot be taken.

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Rosiglitazone tablet
What is this medicine?

ROSIGLITAZONE helps to treat type 2 diabetes. It helps to control blood sugar. Treatment is combined with diet and exercise.
What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
diabetic ketoacidosis
heart disease
heart failure
kidney disease
liver disease
macular edema
polycystic ovary syndrome
swelling of the arms, legs, or feet
taking insulin
taking nitrates for chest pain
an unusual or allergic reaction to rosiglitazone, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
How should I use this medicine?

Take this medicine by mouth with a glass of water. You can take this medicine with or without food. Take your medicine at the same time each day. Do not take more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What may interact with this medicine?
gemfibrozil
nitrates like amyl nitrite, isosorbide dinitrate, isosorbide mononitrate, nitroglycerin
other medicines for diabetes, especially insulin
rifampin

Many medications may cause an increase or decrease in blood sugar, these include:
alcohol containing beverages
aspirin and aspirin-like drugs
chloramphenicol
chromium
diuretics
female hormones, like estrogens or progestins and birth control pills
heart medicines
isoniazid
male hormones or anabolic steroids
medicines for weight loss
medicines for allergies, asthma, cold, or cough
medicines for mental problems
medicines called MAO Inhibitors like Nardil, Parnate, Marplan, Eldepryl
niacin
NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
pentamidine
phenytoin
probenecid
quinolone antibiotics like ciprofloxacin, levofloxacin, ofloxacin
some herbal dietary supplements
steroid medicines like prednisone or cortisone
thyroid medicine

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress.

Your health care professional will have to check blood tests regularly to assess the effect of this medication on your liver.

Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.

If you have low blood sugar, eat or drink something that has sugar. Make sure others know to get medical help quickly if you have serious symptoms of low blood sugar, like if you become unconscious or have a seizure.

This medicine may increase your risk of having some heart problems. Get medical help right away if you have any chest pain or tightness, or pain that radiates to the jaw or down the arm, and shortness of breath. These may be signs of a serious medical condition.

This medicine may cause ovulation in premenopausal women who do not have regular monthly periods. This may increase your chances of becoming pregnant. You should not take this medicine if you become pregnant or think you may be pregnant. Talk with your doctor or health care professional about your birth control options while taking this medicine. Contact your doctor or health care professional right away if think you are pregnant.

If you need surgery or if you will need a procedure with contrast drugs, tell your doctor or health care professional that you are taking this medicine.

Wear a medical identification bracelet or chain to say you have diabetes, and carry a card that lists all your medications.
What side effects may I notice from this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
bone or joint pain
breathing problems
chest pain or tightness
dark urine
fever or chills, sore throat
low blood sugar (ask your doctor or healthcare professional for a list of these symptoms)
muscle pain
pain that radiates to the jaw or down the arm
sudden weight gain
swelling of the ankles, feet, hands
unusually weak or tired
yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
back ache
diarrhea
dizziness
headache
slow weight gain

This list may not describe all possible side effects.
Where should I keep my medicine?

Keep out of the reach of children

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep container tightly closed and protect from light. Throw away any unused medicine after the expiration date.
What is the shelf life of the pills?
The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured..



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Avandia Drug Interactions



Avandia

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IRBESARTAN (Systemic)


Some commonly used brand names are:

In the U.S.—
Avapro
Category
Antihypertensive
Description

Irbesartan (ir-be-SAR-tan) belongs to the class of medicines called angiotensin II inhibitor antihypertensives. It is used to treat high blood pressure (hypertension).

High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure also may increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

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Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to irbesartan. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Use of irbesartan during pregnancy, especially during the second and third trimesters (after the first 3 months), can cause low blood pressure, severe kidney failure, or even death in the newborn. Therefore, it is important that you check with your doctor immediately if you think that you may have become pregnant . Be sure that you have discussed this with your doctor before taking this medicine.

Breast-feeding—It is not known whether irbesartan passes into breast milk. However, irbesartan passes into the milk of lactating rats. Because this medicine may cause serious side effects, breast-feeding is generally not recommended while you are taking it.

Children—This medicine has been tested in children over 6 years of age and has not been shown to cause different side effects or problems than it does in adults.

Older adults—This medicine has been tested in patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults. However, blood levels of irbesartan may be increased in the elderly and elderly patients may be more sensitive to the effects of irbesartan.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking irbesartan, it is especially important that your health care professional know if you are taking any of the following:
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Congestive heart failure, severe—Lowering of blood pressure by irbesartan may make this condition worse
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